Home > Signaling Pathways>Anti-infection>Bacterial>Nanchangmycin (Nanchangmycin A)
Nanchangmycin (Nanchangmycin A)

This product is for research use only, not for human use. We do not sell to patients.

Nanchangmycin (Nanchangmycin A)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$980Check With Us
250mg$1850Check With Us
500mg$2775Check With Us
email: [email protected]        [email protected]

Cat #: V2063 CAS #: 65101-87-3 Purity ≥ 99%

Description: Nanchangmycin (Nanchangmycin A) is a polyether antibiotic isolated from Streptomyces nanchangensis NS3226 with similar structure to dianemycin. It is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants. Nanchangmycin inhibits gram-positive bacteria and can be used as a growth promotant in poultry and to cure coccidiosis in chickens.

References: [1]. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)889.1
Molecular FormulaC48H80O13
CAS No.65101-87-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 173 mg/mL (194.6 mM)r
Water: <1 mg/mLr
Ethanol: 173 mg/mL (194.6 mM)
SMILES CodeC[C@H]([C@@H](O1)[C@H](C)[C@@H](O)C[C@@]21CC[C@@](C)([C@@H](C[C@H](OC3O[C@H](C)[C@@H](OC)CC3)[C@H]4C)O[C@]54[C@@H](C)C[C@H]([C@H]6O[C@](CO)(O)[C@H](C)C[C@@H]6C)O5)O2)/C=C(C)/C([C@H](C)C[C@H](C)C([O-])=O)=O.[Na+]
SynonymsCCRIS 8440; CCRIS-8440; CCRIS8440; Nanchangmycin A
ProtocolIn VitroNanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.1247 mL5.6237 mL11.2473 mL22.4947 mL
5mM0.2249 mL1.1247 mL2.2495 mL4.4989 mL
10mM0.1125 mL0.5624 mL1.1247 mL2.2495 mL
20mM0.0562 mL0.2812 mL0.5624 mL1.1247 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.