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Naloxone HCl

This product is for research use only, not for human use. We do not sell to patients.

Naloxone HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$250Check With Us
2g$400Check With Us
5g$900Check With Us
email: [email protected]        [email protected]

Cat #: V3775 CAS #: 357-08-4 Purity ≥ 98%

Description: Naloxone HCl is an inverse opioid agonist drug used to counteract the effects of opiate overdose.

References: J Pharmacol Exp Ther. 2000 May;293(2):607-17; Psychopharmacology (Berl). 1999 Mar;142(3):302-8.

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Molecular Weight (MW)363.84
Molecular FormulaC19H21NO4.HCl
CAS No.357-08-4
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 73 mg/mL (200.6 mM)rr
Water: 73 mg/mL (200.6 mM)rr
Ethanol: <1 mg/mL
SMILES Code O=C1[C@@](OC2=C(O)C=CC3=C24)([H])[C@@]54CCN(CC=C)[C@@](C3)([H])[C@]5(O)CC1.[H]Cl
SynonymsNaloxone HCl; Narcan; Narcanti; Nalonee; EN-15304; EN15304; EN 15304; NIH7890
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7485 mL13.7423 mL27.4846 mL54.9692 mL
5mM0.5497 mL2.7485 mL5.4969 mL10.9938 mL
10mM0.2748 mL1.3742 mL2.7485 mL5.4969 mL
20mM0.1374 mL0.6871 mL1.3742 mL2.7485 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.