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nAChR agonist 1

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nAChR agonist 1
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Cat #: V37652 CAS #: 1394371-75-5 Purity ≥ 99%

Description: nAChR agonist 1 is a novel, brain-permeable, and orally bioavailable positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR).

References: Sinha N, et al.Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relati

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Molecular Weight (MW)419.938 
Molecular FormulaC20H18ClNO3S2
CAS No.1394371-75-5
SMILES CodeNS(C1=CC=C(C2=C(C(CC)=O)SC(C3=CC=C(Cl)C=C3)=C2C)C=C1)(=O)=O
SynonymsnAChR agonist 1 
ProtocolIn VivoAcute (single-dose) oral administration of nAChR agonist 1 (compound 28) prior to memory acquisition, significantly increased the discrimination index in both time-delay and scopolamine-induced 8 amnesia at 1 and 3 mg/kg dose levels in male Wistar rats.nAChR agonist 1 also significantly improved the discrimination index in the memory consolidation paradigm, when administered immediately after the memory acquisition trial
Animal modelMale BALB/c mice
Dosages10 mg/kg
Administrationp.o.(Pharmacokinetic Analysis)
These protocols are for reference only. InvivoChem does not independently validate these methods.
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.