N-piperidine Ibrutinib HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | To Be Confirmed |
| 200mg | $1875 | To Be Confirmed |
| 500mg | $3165 | To Be Confirmed |
: Cat #: V39041 CAS #: 2231747-18-3 Purity ≥ 99%
Description: N-piperidine Ibrutinib HCl, the hydrochloride salt of N-piperidine Ibrutinib, is an intermediate used in the synthesis of BTK-targeted PROTACs such as SJF620 (DC50 of 7.9 nM for degrading BTK).
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| Molecular Weight (MW) | 422.91 |
|---|---|
| Molecular Formula | C22H23ClN6O |
| CAS No. | 2231747-18-3 |
| SMILES Code | NC1=C2C(N(C3CCNCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1.[H]Cl |
| Synonyms | N-piperidine Ibrutinib hydrochloride; N-piperidine Ibrutinib (hydrochloride); 2231747-18-3; 3-(4-phenoxyphenyl)-1-piperidin-4-ylpyrazolo[3,4-d]pyrimidin-4-amine;hydrochloride; SCHEMBL21331506 |
| Protocol | In Vitro | N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC50s of 374, 162, and 8.3 nM, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3646 mL | 11.8228 mL | 23.6457 mL | 47.2914 mL |
| 5mM | 0.4729 mL | 2.3646 mL | 4.7291 mL | 9.4583 mL |
| 10mM | 0.2365 mL | 1.1823 mL | 2.3646 mL | 4.7291 mL |
| 20mM | 0.1182 mL | 0.5911 mL | 1.1823 mL | 2.3646 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.