N-Desmethyl Apalutamide

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$3700	To Be Confirmed
200mg	$5500	To Be Confirmed
500mg	$8800	To Be Confirmed

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Cat #: V40329 CAS #: 1332391-11-3 Purity ≥ 99%

Description: N-Desmethyl Apalutamide is the CYP2C8 and CYP3A4-mediated, N-demethylated and active metabolite of Apalutamide, but the potency is less than the parent drug. Apalutamide (JNJ-56021927; ARN-509; Erleada) is an approved anticancer drug that acts as an AR/androgen receptor inhibitor.

References: [1]. Pérez-Ruixo C, et al. Population Pharmacokinetics of Apalutamide and its Active Metabolite N-Desmethyl-Apalutamide in Healthy and Castration-Resistant Prostate Cancer Subjects. Clin Pharmacokinet. 2019 Aug 20.

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Molecular Weight (MW)	463.41
Molecular Formula	C20H13F4N5O2S
CAS No.	1332391-11-3
SMILES Code	FC(F)(F)C1=C(C#N)N=CC(N2C(C3(CCC3)N(C4=CC(F)=C(C(N)=O)C=C4)C2=S)=O)=C1
Synonyms	N-Desmethyl Apalutamide;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1579 mL	10.7896 mL	21.5792 mL	43.1583 mL
5mM	0.4316 mL	2.1579 mL	4.3158 mL	8.6317 mL
10mM	0.2158 mL	1.0790 mL	2.1579 mL	4.3158 mL
20mM	0.1079 mL	0.5395 mL	1.0790 mL	2.1579 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.