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N-Boc-PEG6-alcohol

This product is for research use only, not for human use. We do not sell to patients.

N-Boc-PEG6-alcohol
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$450Check With Us
1g$650Check With Us
5g$1645Check With Us
email: [email protected]        [email protected]

Cat #: V26300 CAS #: 331242-61-6 Purity ≥ 99%

Description: N-Boc-PEG6-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.

References: Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.

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Molecular Weight (MW)381.46
Molecular FormulaC17H35NO8
CAS No.331242-61-6
SMILES CodeO=C(OC(C)(C)C)NCCOCCOCCOCCOCCOCC
SynonymsN-Boc-PEG6-alcohol
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6215 mL13.1075 mL26.2151 mL52.4301 mL
5mM0.5243 mL2.6215 mL5.2430 mL10.4860 mL
10mM0.2622 mL1.3108 mL2.6215 mL5.2430 mL
20mM0.1311 mL0.6554 mL1.3108 mL2.6215 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.