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N-Boc-PEG4-alcohol

This product is for research use only, not for human use. We do not sell to patients.

N-Boc-PEG4-alcohol
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$380Check With Us
1g$550Check With Us
5g$1390Check With Us

Cat #: V26297 CAS #: 106984-09-2 Purity ≥ 99%

Description: N-Boc-PEG4-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.

References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Product Promise

Promise
Molecular Weight (MW)293.36
Molecular FormulaC13H27NO6
CAS No.106984-09-2
SMILES CodeO=C(OC(C)(C)C)NCCOCCOCCOCC
SynonymsN-Boc-PEG4-alcohol
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.4088 mL17.0439 mL34.0878 mL68.1756 mL
5mM0.6818 mL3.4088 mL6.8176 mL13.6351 mL
10mM0.3409 mL1.7044 mL3.4088 mL6.8176 mL
20mM0.1704 mL0.8522 mL1.7044 mL3.4088 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.