N-Acetyl-Calicheamicin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$7200	Check With Us
200mg	$10800	Check With Us
500mg	$14880	Check With Us

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Cat #: V33969 CAS #: 108212-76-6 Purity ≥ 99%

Description: N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin), the N-acetylated analog of calicheamicin, is a novel and potent antitumor antibiotic of the enediyne class.

References: Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

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Molecular Weight (MW)	1410.39
Molecular Formula	C57H76IN3O22S4
CAS No.	108212-76-6
SMILES Code	O=C1C[C@]2(O)/C(C([C@]([H])(C#C/C=C\C#C2)O[C@@H]3O[C@H](C)[C@@H](NO[C@@H]4O[C@H](C)[C@@H](SC(C5=C(C)C(I)=C(O[C@H]6[C@H](O)[C@H](OC)[C@@H](O)[C@H](C)O6)C(OC)=C5OC)=O)[C@@H](O)C4)[C@H](O)[C@H]3O[C@H]7C[C@H](OC)[C@@H](N(CC)C(C)=O)CO7)=C1NC(OC)=O)=C\CSSSC
Synonyms	N-Acetylcalicheamicin γ; N-Acetyl calicheamicin; N-Acetyl-γ-calicheamicin;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.7090 mL	3.5451 mL	7.0902 mL	14.1805 mL
5mM	0.1418 mL	0.7090 mL	1.4180 mL	2.8361 mL
10mM	0.0709 mL	0.3545 mL	0.7090 mL	1.4180 mL
20mM	0.0355 mL	0.1773 mL	0.3545 mL	0.7090 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.