Mupirocin calcium hydrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $350 | Check With Us |
| 500mg | $450 | Check With Us |
| 1g | $675 | Check With Us |
: Cat #: V37711 CAS #: 115074-43-6 Purity ≥ 99%
Description: Mupirocin (BRL-4910A; Pseudomonic acid) is an potent isoleucyl t-RNA synthetase inhibitor and an orally bioactive antibiotic isolated from Pseudomonas fluorescens.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 538.68 |
|---|---|
| Molecular Formula | C26H46O10 |
| CAS No. | 115074-43-6 |
| SMILES Code | O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]2CO[C@@H](CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)[C@H](O)[C@@H]2O.C[C@H](O)[C@H](C)[C@@H]3O[C@H]3C[C@H]4CO[C@@H](CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)[C@H](O)[C@@H]4O |
| Synonyms | Mupirocin Calcium Hydrate; Mupirocin calcium salt; Calcium Mupirocin Dihydrate |
| Protocol | In Vitro | Mupirocin calcium hydrate is highly bound (95% bound) to human serum protein, thus results in activity inhibition in the presence of human serum. Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate (0-100 μM; 48 h) shows antibacterial effect against staphylococci, streptococci and certain gram-negative bacteria, with MIC values range from 0.06-0.25 μg/mL (MIC50 =0.12 μg/mL, MIC90 =0.25 μg/mL). |
|---|---|---|
| In Vivo | Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A. | |
| Animal model | MRSA skin infection model in mice (10-12 weeks old) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8564 mL | 9.2819 mL | 18.5639 mL | 37.1278 mL |
| 5mM | 0.3713 mL | 1.8564 mL | 3.7128 mL | 7.4256 mL |
| 10mM | 0.1856 mL | 0.9282 mL | 1.8564 mL | 3.7128 mL |
| 20mM | 0.0928 mL | 0.4641 mL | 0.9282 mL | 1.8564 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.