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MTX-211

This product is for research use only, not for human use. We do not sell to patients.

MTX-211
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Size Price Stock
100mg$2100Check With Us
200mg$3150Check With Us
500mg$5315Check With Us
email: [email protected]        [email protected]

Cat #: V5224 CAS #: 1952236-05-3 Purity ≥ 98%

Description: MTX-211 is a novel and potent dual inhibitor of EGFR and PI3K with the potential to be used for the treatment of cancer, in particular KRAS mutant colorectal cancer.

References: Small molecule inhibitors of egfr and pi3k. WO 2016100347 A2

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Molecular Weight (MW)478.33
Molecular FormulaC20H14Cl2FN5O2S
CAS No.1952236-05-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeCS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O
SynonymsMTX-211; MTX211; MTX 211
ProtocolIn VitroMTX-211 (MOL211) has inhibitory activity for both EGFR and PI3K Alpha with IC50 values of ＜100 nM.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0906 mL10.4530 mL20.9061 mL41.8121 mL
5mM0.4181 mL2.0906 mL4.1812 mL8.3624 mL
10mM0.2091 mL1.0453 mL2.0906 mL4.1812 mL
20mM0.1045 mL0.5227 mL1.0453 mL2.0906 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.