MS023 dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | To Be Confirmed |
| 250mg | $1950 | To Be Confirmed |
| 500mg | $2925 | To Be Confirmed |
: Cat #: V31954 CAS #: 1992047-64-9 Purity ≥ 99%
Description: MS023 DiHCl (MS-023), the dihydrochloride salt of MS-023, is a PRMTs (Protein arginine methyltransferases) inhibitor with potential anticancer activity.
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| Molecular Weight (MW) | 360.32 |
|---|---|
| Molecular Formula | C17H27Cl2N3O |
| CAS No. | 1992047-64-9 |
| Synonyms | MS023 dihydrochloride |
| Protocol | In Vitro | MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells. MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells. |
|---|---|---|
| In Vivo | Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7753 mL | 13.8766 mL | 27.7531 mL | 55.5062 mL |
| 5mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 11.1012 mL |
| 10mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 5.5506 mL |
| 20mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 2.7753 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.