MRGPRX1 agonist 1

This product is for research use only, not for human use. We do not sell to patients.

MRGPRX1 agonist 1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1950Check With Us
500mg$3250Check With Us
1g$4875Check With Us

Cat #: V2517 CAS #: 2377379-39-8 Purity ≥ 99%

Description: MRGPRX1 agonist 1 is a novel and highly potent agonist of MRGPRX1 (Mas-related G-protein-coupled receptor X1) (EC50 = 50 nM) with analgesic effects.

References: Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641.

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Molecular Weight (MW)435.50
Molecular FormulaC23H21N3O4S
CAS No.2377379-39-8
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2962 mL11.4811 mL22.9621 mL45.9242 mL
5mM0.4592 mL2.2962 mL4.5924 mL9.1848 mL
10mM0.2296 mL1.1481 mL2.2962 mL4.5924 mL
20mM0.1148 mL0.5741 mL1.1481 mL2.2962 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.