Moxifloxacin HCl (BAY12-8039)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$590	Check With Us
5g	$1050	Check With Us
10g	$1575	Check With Us

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Cat #: V1416 CAS #: 186826-86-8 Purity ≥ 98%

Description: Moxifloxacin HCl (formerly BAY12-8039; BAY12-8039; BAY 12-8039; Avelox, Avalox, Avelon, Vigamox, Moxeza),the hydrochloride salt of moxifloxacin, is an orally bioactive, broad spectrum and 4th generation antibacterial drug of the fluoroquinolone class with high activity against both Gram positive and Gram negative bacteria.

References: Ioannidis O, et al. Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia. Microbiol Immunol. 2014 Feb;58(2):96-102.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	437.89
Molecular Formula	C21H24FN3O4.HCl
CAS No.	186826-86-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 88 mg/mL (201 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
Synonyms	BAY12-8039 HCl; BAY-12-8039; BAY128039; BAY-128039; BAY 128039; Moxifloxacin, BAY12-8039; BAY 12-8039; Avelox, Avalox, Avelon, Vigamox, Moxeza

Protocol	In Vivo	Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic
	Animal model	144 white male Wistar rats (18-22 weeks; 300-400 g) infected Stenotrophomonas maltophilia
	Dosages	12 mg/kg
	Administration	Intravenous injection; once per day, twice per day, three times per day; for 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2837 mL	11.4184 mL	22.8368 mL	45.6736 mL
5mM	0.4567 mL	2.2837 mL	4.5674 mL	9.1347 mL
10mM	0.2284 mL	1.1418 mL	2.2837 mL	4.5674 mL
20mM	0.1142 mL	0.5709 mL	1.1418 mL	2.2837 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.