Mofezolac

This product is for research use only, not for human use. We do not sell to patients.

Mofezolac
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$1103-6 Days
25mg$2203-6 Days
50mg$3503-6 Days
100mg$5003-6 Days
250mg$7903-6 Days
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V2740 CAS #: 78967-07-4 Purity ≥ 99%

Description: Mofezolac (formerly known as N-22; trade name in Japan: Disopain) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000. It is a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic and anti-inflammatory drug for the treatment of rheumatoid arthritis, lower back pain, frozen shoulder, and pain management after surgery or trauma. Mofezolac has the potential to treat pain, musculoskeletal pain, and arthritis. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the inflammation, are the pharmacological targets of non-steroidal anti-inflammatory drugs, used to treat pain and inflammation. The capability of P6 and mofezolac to modulate the NF-kB signaling pathway, emphasizing the neuroprotective effect and therapeutic potential of COX-1 inhibitors in the control of neuroinflammatory diseases.

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Molecular Weight (MW)339.35
Molecular FormulaC19H17NO5
CAS No.78967-07-4
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsN-22; N 22; N22; Mofezolac; Disopain
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9468 mL14.7341 mL29.4681 mL58.9362 mL
5mM0.5894 mL2.9468 mL5.8936 mL11.7872 mL
10mM0.2947 mL1.4734 mL2.9468 mL5.8936 mL
20mM0.1473 mL0.7367 mL1.4734 mL2.9468 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.