MM-401
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3900 | Check With Us |
| 200mg | $5850 | Check With Us |
| 500mg | $9870 | Check With Us |
: Cat #: V22884 CAS #: 1442106-10-6 Purity ≥ 98%
Description: MM-401 is a novel, potent and selective inhibitor of histone H3K4 methyltransferase MLL1 activity.
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| Molecular Weight (MW) | 586.73 |
|---|---|
| Molecular Formula | C29H46N8O5 |
| CAS No. | 1442106-10-6 |
| SMILES Code | CC(C)C(N[C@@]1(C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC)C(N[C@H](C2=CC=CC=C2)C(NCCCC1)=O)=O)=O)=O)=O |
| Synonyms | MM 401; MM-401; MM401 |
| Protocol | In Vitro | MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells. MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly. MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7044 mL | 8.5218 mL | 17.0436 mL | 34.0872 mL |
| 5mM | 0.3409 mL | 1.7044 mL | 3.4087 mL | 6.8174 mL |
| 10mM | 0.1704 mL | 0.8522 mL | 1.7044 mL | 3.4087 mL |
| 20mM | 0.0852 mL | 0.4261 mL | 0.8522 mL | 1.7044 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.