MLN0905
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | Check With Us |
| 500mg | $2550 | Check With Us |
| 1g | $3825 | Check With Us |
: Cat #: V1578 CAS #: 1228960-69-7 Purity ≥ 98%
Description: MLN0905 (MLN-0905; MLN 0905) is a novel, potent and selective small-molecule inhibitor of polo-like kinase-1 (PLK1) with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 486.56 |
|---|---|
| Molecular Formula | C24H25F3N6S |
| CAS No. | 1228960-69-7 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 97 mg/mL (199.4 mM)rr |
| Water:<1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | PLK1 inhibitor; MLN0905; MLN 0905; MLN-0905 |
| Protocol | In Vitro | MLN0905 (compound 12c) has inhibitory effect on PLK1, IC50 The value is 2 nM. MLN0905 has potent activity against Cdc25C, EC50 The value is 33 nM。 MLN0905 has inhibitory effects on HT29, HCT116, H460, and A375 cell lines, LD50 The values are 22 nM, 56 nM, 89 nM, and 34 nM, respectively. MLN0905 (125 nM) exhibits intense mitotic arrest and unipolar spindle formation in HT-29 cells. |
|---|---|---|
| In Vivo | MLN0905 (p.o.; 50 mg/kg) demonstrated a highly sustained PD response in nude mouse HT29 xenograft tumors | |
| Animal model | Tumor (HT29) xenograft model | |
| Dosages | 0-50 mg/kg | |
| Administration | P.O; daily, QD×3/week |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0552 mL | 10.2762 mL | 20.5524 mL | 41.1049 mL |
| 5mM | 0.4110 mL | 2.0552 mL | 4.1105 mL | 8.2210 mL |
| 10mM | 0.2055 mL | 1.0276 mL | 2.0552 mL | 4.1105 mL |
| 20mM | 0.1028 mL | 0.5138 mL | 1.0276 mL | 2.0552 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.