Home > Signaling Pathways>Autophagy>LRRK2>MLi-2
MLi-2

This product is for research use only, not for human use. We do not sell to patients.

MLi-2
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1125Check With Us
200mg$1685Check With Us
500mg$2840Check With Us
email: [email protected]        [email protected]

Cat #: V25704 CAS #: 1627091-47-7 Purity ≥ 99%

Description: MLi-2 (MLi2) is a novel, highly potent, orally bioactive, and selective LRRK2 (Leucine-Rich Repeat Kinase 2) kinase inhibitor (IC50 = 0.76 nM) with CNS (central nervous system) activity, and thus has the potential for treating Parkinson's disease.

References: Fell MJ, et al. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)379.46
Molecular FormulaC21H25N5O2
CAS No.1627091-47-7
SMILES Code CC1(OC2=CC3=C(NN=C3C4=CC(N5C[C@H](C)O[C@H](C)C5)=NC=N4)C=C2)CC1
SynonymsMLi-2; MLi 2; MLi2.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6353 mL13.1766 mL26.3532 mL52.7065 mL
5mM0.5271 mL2.6353 mL5.2706 mL10.5413 mL
10mM0.2635 mL1.3177 mL2.6353 mL5.2706 mL
20mM0.1318 mL0.6588 mL1.3177 mL2.6353 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.