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| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | 3-6 Days |
| 10mg | $260 | 3-6 Days |
| 25mg | $430 | 3-6 Days |
| 50mg | $640 | 3-6 Days |
| 100mg | $860 | 3-6 Days |
| 250mg | $1060 | 3-6 Days |
| 500mg | $1370 | 3-6 Days |
: Cat #: V2626 CAS #: 2029049-79-2 Purity ≥ 99%
Description: ML390 is a novel potent inhibitor of human DHODH (Dihydroorotate dehydrogenase) that induces differentiation in acute myeloid leukemia (AML) with EC50 of 1.8μM, 8.8μM, 6.5μM, and 0.56μM in ER-HOX-GFP, U937, THP-1 cells and DHODH enzyme, respectively. ML390 was identified as the most potent compound against the engineered ERHOX-GFP cell line. Moreover, the addition of uridine to the cell culture media could abrogate the differentiation effects of ML390, demonstrating further evidences that ML390’ effects were due to their inhibition of DHODH-catalyzed pyrimidine synthesis. Therefore, ML390 may offer insight into the mechanism of overcoming differentiation arrest, and has the potential to used as a treatment for patients with AML.
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| Molecular Weight (MW) | 406.398256063461 |
|---|---|
| Molecular Formula | C21H21F3N2O3 |
| CAS No. | 2029049-79-2 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | ML390; ML-390 ML 390 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4606 mL | 12.3032 mL | 24.6064 mL | 49.2128 mL |
| 5mM | 0.4921 mL | 2.4606 mL | 4.9213 mL | 9.8426 mL |
| 10mM | 0.2461 mL | 1.2303 mL | 2.4606 mL | 4.9213 mL |
| 20mM | 0.1230 mL | 0.6152 mL | 1.2303 mL | 2.4606 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.