ML381

This product is for research use only, not for human use. We do not sell to patients.

ML381
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$90To Be Confirmed
5mg$250To Be Confirmed
10mg$430To Be Confirmed
email: [email protected]        [email protected]

Cat #: V25688 CAS #: 1623481-80-0 Purity ≥ 99%

Description: ML381 (VU0488130) is a selective, CNS-penetrating mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be used primarily as a molecular probe for in vitro and electrophysiological studies.

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Molecular Weight (MW)379.409145116806
Molecular FormulaC21H21N3O4
CAS No.1623481-80-0
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsML 381ML-381 VU0488130 VU-0488130 ML381
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6357 mL13.1784 mL26.3568 mL52.7135 mL
5mM0.5271 mL2.6357 mL5.2714 mL10.5427 mL
10mM0.2636 mL1.3178 mL2.6357 mL5.2714 mL
20mM0.1318 mL0.6589 mL1.3178 mL2.6357 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.