ML380 | CAS 1627138-52-6

ML380

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10mg	$110	To Be Confirmed
50mg	$360	To Be Confirmed
100mg	$600	To Be Confirmed

: sales@invivochem.com sales@invivochem.cn

Cat #: V13797 CAS #: 1627138-52-6 Purity ≥ 99%

Description: ML380 is a potent, isoform-selective and BBB (blood-brain barrier) permeable/penetrable M5 mAChR positive allosteric modulator (PAM) with EC50s for human and rat M5 of 190 and 610 nM, respectively. ML380 is moderately selective for the M1 and M3 mAChR subtypes. ML380 can increase the affinity of ACh for M5 mAChR.

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Molecular Weight (MW)	494.53
Molecular Formula	C23H25F3N4O3S
CAS No.	1627138-52-6
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Synonyms	ML-380; ML 380; ML380

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0221 mL	10.1106 mL	20.2212 mL	40.4424 mL
5mM	0.4044 mL	2.0221 mL	4.0442 mL	8.0885 mL
10mM	0.2022 mL	1.0111 mL	2.0221 mL	4.0442 mL
20mM	0.1011 mL	0.5055 mL	1.0111 mL	2.0221 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.