ML348
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $920 | Check With Us |
| 500mg | $1475 | Check With Us |
| 1g | $2215 | Check With Us |
: Cat #: V2945 CAS #: 899713-86-1 Purity ≥ 98%
Description: ML348 (also known as CID 3238952; SID 160654487) is a reversible inhibitor of LYPLA1 (Lysophospholipase 1) with an IC50 value of 210 nM.
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| Molecular Weight (MW) | 415.79 |
|---|---|
| Molecular Formula | C18H17ClF3N3O3 |
| CAS No. | 899713-86-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mM in DMSOr |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2 |
| Synonyms | CID 3238952; SID 160654487; ML348; ML-348; ML 348; GNF-Pf-1127; GNF Pf-1127; GNF-Pf 1127 |
| Protocol | In Vitro | ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells. |
|---|---|---|
| In Vivo | ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4051 mL | 12.0253 mL | 24.0506 mL | 48.1012 mL |
| 5mM | 0.4810 mL | 2.4051 mL | 4.8101 mL | 9.6202 mL |
| 10mM | 0.2405 mL | 1.2025 mL | 2.4051 mL | 4.8101 mL |
| 20mM | 0.1203 mL | 0.6013 mL | 1.2025 mL | 2.4051 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.