MK-886 (L-663536)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1580 | Check With Us |
| 1g | $2370 | Check With Us |
: Cat #: V4328 CAS #: 118414-82-7 Purity ≥ 98%
Description: MK886 ( also known as L 663536) is a novel and potent 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 472.08 |
|---|---|
| Molecular Formula | C27H34ClNO2S |
| CAS No. | 118414-82-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)C(C)(C)CC(N1CC2=CC=C(Cl)C=C2)=C(SCCCC)C3=C1C=CC(C(C)C)=C3 |
| Synonyms | L-663,536; L663,536; L 663,536; L-663536; L663536; L 663536; MK-886; MK886; MK 886; |
| Protocol | In Vitro | MK-886 (0.5-2 µM; 15 hours; primary keratinocytes) treatment reduces keratin-1 expression in a culture of mouse primary keratinocytes. Although Jurkat cells express all PPAR isoforms, various PPARα and PPARγ agonists are unable to prevent MK-886-induced apoptosis. Using a transient transfection system in monkey kidney fibroblast CV-1 cells, mouse keratinocyte 308 cells and human lung adenocarcinoma A549 cells, 10 µM MK-886 is able to inhibit Wy-14643 activation of PPARα by ~80%. MK-886 also decreases PPARα activation by fatty acids in the stable transfection system. |
|---|---|---|
| In Vivo | MK-886 (L 663536; 5 mg/kg; oral administration; male Sprague-Dawley rats) treatment potently inhibits the antigen-induced dyspnea in inbred rats pretreated with methysergide. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1183 mL | 10.5914 mL | 21.1829 mL | 42.3657 mL |
| 5mM | 0.4237 mL | 2.1183 mL | 4.2366 mL | 8.4731 mL |
| 10mM | 0.2118 mL | 1.0591 mL | 2.1183 mL | 4.2366 mL |
| 20mM | 0.1059 mL | 0.5296 mL | 1.0591 mL | 2.1183 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.