MK-8776 (SCH 900776)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2975 | Check With Us |
: Cat #: V1584 CAS #: 891494-63-6 Purity ≥ 98%
Description: MK-8776 (also known as SCH900776; MK8776; SCH-900776; MK 8776) is a novel, highly potent and selective Chk1 (cell cycle checkpoint kinase 1) inhibitor with potential antineoplastic, radiosensitization and chemosensitization activities.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 376.25 |
|---|---|
| Molecular Formula | C15H18BrN7 |
| CAS No. | 891494-63-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 3 mg/mL (8.0 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 4% DMSO+30% Propylene glycol: 5 mg/mL |
| Synonyms | SCH900776; MK8776; SCH-900776; MK-8776; SCH 900776; MK 8776 |
| Protocol | In Vitro | SCH 900776 K to the CHK1 kinase domaind The value is 2 nM. SCH 900776 exhibits approximately 32065 nM EC in cells exposed to NSC-6050。 SCH 900776 induces dose-dependent inhibition of CHK2 pS1 and concomitant accumulation of phosphorylated RPA signaling in U296OS cells |
|---|---|---|
| In Vivo | SCH 900776 induced γ-H4AX biomarkers at 2 mg/kg (i.p.) and enhanced tumor pharmacodynamics and regression responses in the A2780 xenograft model. SCH 900776 (16 and 32 mg/kg, intraperitoneally) induces gradual improvement in tumor response. Increasing the SCH 900776 dose to 20 and 50 mg/kg in combination with LY 188011 increases TTP by a factor of 2780 in the A10 xenograft system |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6578 mL | 13.2890 mL | 26.5781 mL | 53.1561 mL |
| 5mM | 0.5316 mL | 2.6578 mL | 5.3156 mL | 10.6312 mL |
| 10mM | 0.2658 mL | 1.3289 mL | 2.6578 mL | 5.3156 mL |
| 20mM | 0.1329 mL | 0.6645 mL | 1.3289 mL | 2.6578 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.