MK-3207
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | To Be Confirmed |
| 500mg | $2550 | To Be Confirmed |
| 1g | $3825 | To Be Confirmed |
: Cat #: V4317 CAS #: 957118-49-9 (free base) Purity ≥ 98%
Description: MK-3207 is a novel, potent and orally bioactive CGRP (Calcitonin gene related peptide) receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, it is highly selective versus human AM1, AM2, CTR, and AMY3.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 557.60 |
|---|---|
| Molecular Formula | C31H29F2N5O3 |
| CAS No. | 957118-49-9 (free base) |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 100 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30mg/mL |
| Synonyms | MK-3207 HCl; MK3207; MK 3207 |
| Protocol | In Vitro | MK-3207 (0.3, 0.6, 1.1, 2.3, 4.5, 9.0 nM; 30 min) potently blocks human α-CGRP-stimulated cAMP responses in human CGRP receptor-expressing HEK293 cells |
|---|---|---|
| In Vivo | MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 µg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81% | |
| Animal model | Adult rhesus monkeys (4.8-12.7 kg; capsaicin-induced) | |
| Dosages | 0.3, 0.6, 2.1, 9.1, 21.2, 60.6 µg/kg | |
| Administration | Intravenous injection; single. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7934 mL | 8.9670 mL | 17.9340 mL | 35.8680 mL |
| 5mM | 0.3587 mL | 1.7934 mL | 3.5868 mL | 7.1736 mL |
| 10mM | 0.1793 mL | 0.8967 mL | 1.7934 mL | 3.5868 mL |
| 20mM | 0.0897 mL | 0.4484 mL | 0.8967 mL | 1.7934 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.