MK-0773
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 250mg | $1750 | Check With Us |
| 500mg | $2625 | Check With Us |
: Cat #: V4324 CAS #: 606101-58-0 Purity ≥ 98%
Description: MK-0773 (PF-05314882) is a novel and potent SARM (selective androgen receptor modulator) that binds to AR with an IC50 of 6.6 nM and with the potential for the prevention and treatment of muscle wasting associated with cancer.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 479.59 |
|---|---|
| Molecular Formula | C27H34FN5O2 |
| CAS No. | 606101-58-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | C[C@@]12[C@@H](C(NCC3=NC4=CC=CN=C4N3)=O)CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])N(C)C(C(F)=C[C@]6(C)[C@@]5([H])CC2)=O |
| Synonyms | MK0773; MK 0773; MK-0773 |
| Protocol | In Vitro | The IC50 of MK-0773 binding to AR is increased 3.5-fold in the presence of 25% rat serum and 13-fold in the presence of 25% human serum, indicating that it binds to serum proteins. The affinity of MK-0773 for AR across species is evaluated using COS cells transfected with AR, and IC50 values are very similar in four species (rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM). |
|---|---|---|
| In Vivo | MK-0773 (6 and 80 mg/kg, s.c.) produces exposure-related stimulatory effects on cortical BFR and LBM in the OVX rat model. MK-0773 (5, 15, and 80 mg/kg, s.c.) increases seminal vesicle weights, and has reduced effects on the prostate. The partial agonism and tissue selectivity of MK-0773 does not translate into differential effects on lipid metabolism in OVX rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0851 mL | 10.4256 mL | 20.8511 mL | 41.7023 mL |
| 5mM | 0.4170 mL | 2.0851 mL | 4.1702 mL | 8.3405 mL |
| 10mM | 0.2085 mL | 1.0426 mL | 2.0851 mL | 4.1702 mL |
| 20mM | 0.1043 mL | 0.5213 mL | 1.0426 mL | 2.0851 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.