MK-0731
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10mg | $1390 | To Be Confirmed |
| 20mg | $2085 | To Be Confirmed |
| 50mg | $3335 | To Be Confirmed |
: Cat #: V16230 CAS #: 845256-65-7 Purity ≥ 99%
Description: MK-0731 (MK0731; MK 0731) is a potent kinesin spindle protein (KSP) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 459.50 |
|---|---|
| Molecular Formula | C25H28F3N3Or2 |
| CAS No. | 845256-65-7 |
| Protocol | In Vitro | MK-0731 (0.415-300 nM; 48 hours) induces apoptosis in A2780 cells, EC50 is 2.7 nM |
|---|---|---|
| In Vivo | MK-0731 (40 mg/kg/day; Subcutaneous injection; for 11 days) inhibited the growth of KB-v tumors with high overexpression of Pgp, while paclitaxel (HY-B0015) had no effect | |
| Animal model | Mice for the dual flank xenograft KB-3-1 and KB-v-1 cells | |
| Dosages | 40 mpk |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1763 mL | 10.8814 mL | 21.7628 mL | 43.5256 mL |
| 5mM | 0.4353 mL | 2.1763 mL | 4.3526 mL | 8.7051 mL |
| 10mM | 0.2176 mL | 1.0881 mL | 2.1763 mL | 4.3526 mL |
| 20mM | 0.1088 mL | 0.5441 mL | 1.0881 mL | 2.1763 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.