Minocycline HCl | CAS 13614-98-7 (HCl)

Minocycline HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
2g	$150	Check With Us
5g	$230	Check With Us
10g	$345	Check With Us

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Cat #: V4872 CAS #: 13614-98-7 (HCl) Purity ≥ 98%

Description: Minocycline HCl (NSC 141993; Periocline; Klinomycin; Minocin; Solodyn; Minocin), the hydrochloride salt of minocycline, is a potent, oral and broad-spectrum tetracycline antibiotic used to treat a number of bacterial infections such as pneumonia.

References: Pourgholami MH, et al. Minocycline inhibits growth of epithelial ovarian cancer. Gynecol Oncol. 2012 May;125(2):433-40.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	493.94
Molecular Formula	C23H28ClN3O7
CAS No.	13614-98-7 (HCl)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	Minocycline hydrochloride (0-100 μM, 24-72 hours) inhibits the proliferation and clonal activity of ovarian cancer cell lines (OVCAR-3, SKOV-3, and A2780)
	In Vivo	Minocycline hydrochloride (0-30 mg/kg orally once daily for 4 weeks) inhibits the growth of OVCAR-3 tumors in female nude mice
	Animal model	Female nude mice (6 weeks old, 9 per group, OVCAR-3 cells were injected s.c. into the left flank of each mouse)
	Dosages	10 or 30 mg/kg
	Administration	Administered orally in the drinking water, initiated on day 8 of cell inoculation, daily for 4 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0245 mL	10.1227 mL	20.2454 mL	40.4907 mL
5mM	0.4049 mL	2.0245 mL	4.0491 mL	8.0981 mL
10mM	0.2025 mL	1.0123 mL	2.0245 mL	4.0491 mL
20mM	0.1012 mL	0.5061 mL	1.0123 mL	2.0245 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.