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Milrebrutinib (AS1763)

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Milrebrutinib (AS1763)
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Cat #: V41554 CAS #: 2227211-00-7 Purity ≥ 99%

Description: Milrebrutinib (AS-1763) is a novel, next-generation and noncovalent BTK (Bruton's Tyrosine Kinase) inhibitor with anticancer and anti-inflammatory activity. BTK has been recognized as a validated drug target for the treatment of B-cell malignances, the emergence of clinical resistance to the first-generation covalent BTK inhibitors is becoming a serious concern. With significant efficacies in vivo tumor xenograft models, Milrebrutinib (AS 1763) has been advanced to phase 1 clinical trials. Reference: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2021 Oct 14;64(19):14129-14141.

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Molecular FormulaC33H31FN6O3
CAS No.2227211-00-7
SMILES Code O=C1N(C2=C(CO)C(C3=NC(N)=NC4=C3C=C(C5=CCN(C6COC6)CC5)N4)=CC=C2)C=CC7=CC(C8CC8)=CC(F)=C71
Synonyms Milrebrutinib; AS1763; ASA-1763; AS 1763; ASA1763;  AS-1763; ASA 1763
The molarity calculator equation
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.