This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 250mg | $950 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V1915 CAS #: 208538-73-2 Purity ≥ 98%
Description: Micafungin Sodium (also known as FK463; Mycamine sodium), an echinocandin antifungal agent, is a novel and potent inhibitor of 1, 3-beta-D-glucan synthesis, which is used as an antifungal drug. Micafungin as an antifungal agent is known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively).
References: [1]. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 1292.26 |
|---|---|
| Molecular Formula | C56H70N9NaO23S |
| CAS No. | 208538-73-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (77.4 mM)r |
| Water: 100 mg/mL (77.4 mM)r | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=S(OC1=CC([C@H](O)[C@@H](O)C(NC(C2N(C(C(NC([C@]([H])(C[C@@H](O)[C@@H](O)NC(C3N(C(C([C@H](O)CC(N)=O)N4)=O)C[C@H](C)[C@@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[C@H](O)C)=O)C[C@H](O)C2)=O)C4=O)=CC=C1O)([O-])=O.[Na+] |
| Synonyms | FK463 Sodium; FK 463 Sodium; FK-463 Sodium; Mycamine; FK-463 |
| Protocol | In Vitro | In vitro activity: Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). Fungus experiment: Micafungin decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). |
|---|---|---|
| In Vivo | In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days. | |
| Animal model | A mouse model with septic Aspergillus fumigatus (A. fumigatus) infection |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.7738 mL | 3.8692 mL | 7.7384 mL | 15.4768 mL |
| 5mM | 0.1548 mL | 0.7738 mL | 1.5477 mL | 3.0954 mL |
| 10mM | 0.0774 mL | 0.3869 mL | 0.7738 mL | 1.5477 mL |
| 20mM | 0.0387 mL | 0.1935 mL | 0.3869 mL | 0.7738 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.