MI-2 (Menin-MLL Inhibitor)
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2650 | Check With Us |
| 1g | $3975 | Check With Us |
: Cat #: V0396 CAS #: 1271738-62-5 Purity ≥ 98%
Description: MI-2 (MI2, Menin-MLL Inhibitor) is a novel, potent and selective inhibitor of menin-MLL interaction with antineoplastic activity.
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| Molecular Weight (MW) | 375.55 |
|---|---|
| Molecular Formula | C18H25N5S2 |
| CAS No. | 1271738-62-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 75 mg/mL (199.7 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: NA | |
| SMILES Code | CCCC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1 |
| Synonyms | MI2 ; Menin-MLL inhibitor 2; MI 2 ; Menin MLL inhibitor 2; MI-2 ; Menin-MLL inhibitor-2; |
| Protocol | In Vitro | Menin-MLL inhibitor MI-2 very effectively blocks proliferation of MLL-AF9 and MLL-ENL transduced BMC, with GI50 values of about 5 μM. Assessment of diverse hydrophobic groups at R1 led to the development of several compounds with IC50 values in the nanomolar range, including MI-2 (IC50= 446±28 nM) and MI-3 (IC50=648±25 nM).The dissociation constants measured for the menin-MLL inhibitors are at the nanomolar level, Kd=158 nM for MI-2. MI-2 can access the protein target and very effectively inhibit the menin-MLL-AF9 interaction in human cells. Furthermore, MI-2 shows only a small effect on the cell growth of E2A-HLF transduced BMC (GI50>50 μM), which may be due to inhibition of the menin interaction with wild-type MLL. Treatment with MI-2 results in GI50 values below 10 μM in MV4;11 (harboring MLL-AF4; GI50=9.5 μM), KOPN-8 (MLL-ENL; GI50=7.2 μM) and ML-2 (MLL-AF6; GI50=8.7 μM), and in MonoMac6 (MLL-AF9; GI50=18 μM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6628 mL | 13.3138 mL | 26.6276 mL | 53.2552 mL |
| 5mM | 0.5326 mL | 2.6628 mL | 5.3255 mL | 10.6510 mL |
| 10mM | 0.2663 mL | 1.3314 mL | 2.6628 mL | 5.3255 mL |
| 20mM | 0.1331 mL | 0.6657 mL | 1.3314 mL | 2.6628 mL |
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Method for preparing in vivo formulation:
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
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ddH2O,mix and clarify.
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