Megestrol Acetate (BDH1298)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$250	Check With Us
50g	$700	Check With Us
100g	$1050	Check With Us

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Cat #: V1769 CAS #: 595-33-5 Purity ≥ 98%

Description: Megestrol acetate (formerly BDH1298, SC10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace; Maygace; Megestil; Niagestin) is a synthetic progestogen derivative that has been approved for use in the treatment of breast cancer and loss of appetite.

References: S A Beck, et al. Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice. Br J Cancer. 1990 Sep;62(3):420-4.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	384.51
Molecular Formula	C24H32O4
CAS No.	595-33-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 33 mg/mL (85.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 15 mg/mL (39.0 mM)
Synonyms	BDH 1298; SC10363; BDH1298; SC 10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace. Maygace; Megestil; Niagestin.

Protocol	In Vivo	595-33-5
	Animal model	Pure strain female NMRI mice (age 6 to 8 weeks)
	Dosages	100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil).
	Administration	Subcutaneously daily over a 7-day period.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6007 mL	13.0036 mL	26.0071 mL	52.0143 mL
5mM	0.5201 mL	2.6007 mL	5.2014 mL	10.4029 mL
10mM	0.2601 mL	1.3004 mL	2.6007 mL	5.2014 mL
20mM	0.1300 mL	0.6502 mL	1.3004 mL	2.6007 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.