ME0328 (ME-0328)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1275 | 3-6 Days |
| 1g | $2050 | 3-6 Days |
| 5g | $6130 |
: Cat #: V0312 CAS #: 1445251-22-8 Purity ≥ 98%
Description: ME0328 (ME-0328) is a novel, potent and selective inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity.
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| Molecular Weight (MW) | 321.37 |
|---|---|
| Molecular Formula | C19H19N3O2 |
| CAS No. | 1445251-22-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 64 mg/mL (199.1 mM)rr |
| Water:<1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | ME 0328; ME0328; ME-0328. |
| Protocol | In Vitro | ME0328 is a potent and selective inhibitor of ARTD3/PARP3 that is active in cells. In in vitro histone H1 modification assay, ME0328 inhibits the transferase activity of ARTD3 with an IC50 of 0.89±0.28 μM. In human A549 cells, ME0328 and ME0355 (at 10 μM) delay the resolution of γH2AX-containing foci that serve as markers for DNA double strand break repair following γ-irradiation (2 Gy). In silico and in vitro physicochemical and metabolic profiling indicated that ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1117 mL | 15.5584 mL | 31.1168 mL | 62.2336 mL |
| 5mM | 0.6223 mL | 3.1117 mL | 6.2234 mL | 12.4467 mL |
| 10mM | 0.3112 mL | 1.5558 mL | 3.1117 mL | 6.2234 mL |
| 20mM | 0.1556 mL | 0.7779 mL | 1.5558 mL | 3.1117 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.