MDL-29951

This product is for research use only, not for human use. We do not sell to patients.

MDL-29951
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$950Check With Us
500mg$1550Check With Us
1g$2325Check With Us

Cat #: V2929 CAS #: 130798-51-5 Purity ≥ 98%

Description: MDL-29951 is a potent glycine antagonist of NMDA (N-methyl-D-aspartate) receptor activation with Ki value of 0.14 μM in an in vitro and in vivo [3H]glycine binding assay.

References: Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep; 262(3):947-56.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)302.11
Molecular FormulaC12H9Cl2NO4
CAS No.130798-51-5
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeO=C(O)CCC1=C(C(O)=O)NC2=C1C(Cl)=CC(Cl)=C2
SynonymsMDL 29,951; MDL-29,951; MDL29,951; MDL 29951; MDL-29951; MDL29951
ProtocolIn VitroMDL 100,748 and MDL 29,951 are approximately 2000 times more selective for glycinate-binding sites than glutamate recognition sites
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3101 mL16.5503 mL33.1005 mL66.2011 mL
5mM0.6620 mL3.3101 mL6.6201 mL13.2402 mL
10mM0.3310 mL1.6550 mL3.3101 mL6.6201 mL
20mM0.1655 mL0.8275 mL1.6550 mL3.3101 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.