MDL-28170 | CAS 88191-84-8

MDL-28170

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$600	Check With Us
500mg	$990	Check With Us
1g	$1485	Check With Us

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Cat #: V28953 CAS #: 88191-84-8 Purity ≥ 99%

Description: MDL-28170 (Calpain Inhibitor III) is a novel potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration. MDL-28170 also block γ-secretase.

References: Chen ZF, et al. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res. 1997 Sep 19;769(1):188-92.

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Molecular Weight (MW)	382.45
Molecular Formula	C22H26N2O4
CAS No.	88191-84-8
SMILES Code	[H]C(C(CC1=CC=CC=C1)NC([C@H](C(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O
Synonyms	MDL 28170; MDL28170; MDL-28170

Protocol	In Vitro	MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.
Protocol	In Vivo	Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6147 mL	13.0736 mL	26.1472 mL	52.2944 mL
5mM	0.5229 mL	2.6147 mL	5.2294 mL	10.4589 mL
10mM	0.2615 mL	1.3074 mL	2.6147 mL	5.2294 mL
20mM	0.1307 mL	0.6537 mL	1.3074 mL	2.6147 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.