MC-VA-PAB-Exatecan

This product is for research use only, not for human use. We do not sell to patients.

MC-VA-PAB-Exatecan
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$250To Be Confirmed
10mg$380To Be Confirmed
50mg$680To Be Confirmed
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V44285 CAS #: 2680543-57-9 Purity ≥ 99%

Description: MC-VA-PAB-Exatecan is a novel drug-linker conjugate used for synthesis of anticancer ADC or PDC. It is composed of an ADC linker (peptide MC-VA-PAB) and Exatecan (DNA topoisomerase I inhibitor).

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Molecular Weight (MW)948.002476215363
Molecular FormulaC50H54FN7O11
CAS No.2680543-57-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.0548 mL5.2742 mL10.5485 mL21.0970 mL
5mM0.2110 mL1.0548 mL2.1097 mL4.2194 mL
10mM0.1055 mL0.5274 mL1.0548 mL2.1097 mL
20mM0.0527 mL0.2637 mL0.5274 mL1.0548 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.