Mavacamten (SAR-439152; MYK-461)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1000 | In Stock |
| 1g | $1500 | In Stock |
| 5g | $4050 | In Stock |
: Cat #: V25070 CAS #: 1642288-47-8 Purity ≥ 98%
Description: Mavacamten (also known as SAR439152; MYK461) is a potent and orally bioactive myosin inhibitor with the potential to be used for the treatment of hypertrophic cardiomyopathy/HCM.
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| Molecular Weight (MW) | 273.336 |
|---|---|
| Molecular Formula | C15H19N3O2 |
| CAS No. | 1642288-47-8 |
| SMILES Code | O=C1N(C(C)C)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O |
| Synonyms | MYK 461; SAR-439152; MYK-461; SAR 439152; SAR439152; MYK461; Mavacamten |
| Protocol | In Vitro | Mavacamten is found to have an IC50 value of 490 nM in the bovine system, 711 nM in the human system, and 2140 nM in the rabbit system, indicating selectivity of >4-fold for cardiac myosin |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6585 mL | 18.2925 mL | 36.5850 mL | 73.1700 mL |
| 5mM | 0.7317 mL | 3.6585 mL | 7.3170 mL | 14.6340 mL |
| 10mM | 0.3659 mL | 1.8293 mL | 3.6585 mL | 7.3170 mL |
| 20mM | 0.1829 mL | 0.9146 mL | 1.8293 mL | 3.6585 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.