Maribavir | CAS 176161-24-3

Maribavir

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1190	To Be Confirmed
250mg	$2050	To Be Confirmed
500mg	$3075	To Be Confirmed

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Cat #: V4957 CAS #: 176161-24-3 Purity ≥ 98%

Description: Maribavir (1263W94; BW-1263W94; GW-1263; SHP-620; GW-257406X; VP-41263; Livtencity), an experimental oral antiviral (anti-CMV) drug candidate, is a novel and potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro with an IC50 of 3 nM.

References: Shannon-Lowe CD, et al. The effects of Maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein. Herpesviridae. 2010 Dec 7;1(1):4.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	376.24
Molecular Formula	C₁₅H₁₉Cl₂N₃O₄
CAS No.	176161-24-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	ClC1=C(Cl)C=C2C(N=C(NC(C)C)N2[C@@H]3[C@@H](O)[C@@H](O)[C@H](CO)O3)=C1
Synonyms	1263-W94; GW-1263; SHP-620; 1263 W94; 1263W-94; BW1263W 94; GW1263; SHP620; BW-1263W94; VP41263; Livtencity; BW 1263W94; VP-41263; GW-257406X; GW257406-X; GW 257406X; GW 257406 X; GW257406X

Protocol	In Vitro	Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a Ki of 10 nM.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6579 mL	13.2894 mL	26.5788 mL	53.1576 mL
5mM	0.5316 mL	2.6579 mL	5.3158 mL	10.6315 mL
10mM	0.2658 mL	1.3289 mL	2.6579 mL	5.3158 mL
20mM	0.1329 mL	0.6645 mL	1.3289 mL	2.6579 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.