MACIMORELIN | CAS 381231-18-1

MACIMORELIN

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Cat #: V3905 CAS #: 381231-18-1 Purity ≥ 98%

Description: Macimorelin (formerly known as UMV-1843; EP-1572; AEZS-130; JMV1843; trade name: Macrilen) is a synthetic small molecule agonist of growth hormone secretagogue receptor that has been approved to diagnose growth hormone deficiency. As a ghrelin agonist, it is orally bioactive and can stimulate the secretion of growth hormone (GH). As of December 2017, it became FDA-approved as a method to diagnose growth hormone deficiency. Traditionally, growth hormone deficiency was diagnosed via means of insulin tolerance test (IST) or glucagon stimulation test (GST). These two means are done parenterally, whereas Macrilen boasts an oral formulation for ease of administration for patients and providers.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	474.55
Molecular Formula	C26H30N6O3
CAS No.	381231-18-1
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	CC(C)(N)C(N[C@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](NC=O)CC3=CNC4=C3C=CC=C4)=O)=O
Synonyms	JMV1843; AEZS130; EP-1572; EP 1572; JMV-1843; JMV 1843; EP1572; AEZS-130; AEZS 130; UMV 1843; Macimorelin

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1073 mL	10.5363 mL	21.0726 mL	42.1452 mL
5mM	0.4215 mL	2.1073 mL	4.2145 mL	8.4290 mL
10mM	0.2107 mL	1.0536 mL	2.1073 mL	4.2145 mL
20mM	0.1054 mL	0.5268 mL	1.0536 mL	2.1073 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.