m-PEG4-acid

This product is for research use only, not for human use. We do not sell to patients.

m-PEG4-acid
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$300To Be Confirmed
1g$470To Be Confirmed
5g$705To Be Confirmed

Cat #: V25864 CAS #: 67319-28-2 Purity ≥ 99%

Description: m-PEG4-acid is a PEG analogue containing a terminal carboxylic acid.

References: Robert Lyon, et al. Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics. WO2015057699A2.

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Molecular Weight (MW)236.26
Molecular FormulaC10H20O6
CAS No.67319-28-2
SMILES CodeOC(CCOCCOCCOCCOC)=O
Synonymsm-PEG4-acid
ProtocolIn VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.2326 mL21.1631 mL42.3263 mL84.6525 mL
5mM0.8465 mL4.2326 mL8.4653 mL16.9305 mL
10mM0.4233 mL2.1163 mL4.2326 mL8.4653 mL
20mM0.2116 mL1.0582 mL2.1163 mL4.2326 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.