LYS 006
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1750 | Check With Us |
| 250mg | $2750 | Check With Us |
| 500mg | $4125 | Check With Us |
: Cat #: v2220 CAS #: 1799681-85-8 Purity ≥ 99%
Description: LYS 006 is a potent Leukotriene A4 hydrolase (LTA4H) inhibitor for the treatment of Hidradenitis Suppurativa.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 392.77 |
|---|---|
| Molecular Formula | C16H14ClFN6O3 |
| CAS No. | 1799681-85-8 |
| SMILES Code | O=C(O)C[C@H](N)CN1N=C(C2=CC=C(OC3=NC=C(Cl)C=C3F)C=C2)N=N1 |
| Synonyms | LYS-006; LYS 006; LYS006; |
| Protocol | In Vitro | LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC50 of 167 nM. LTA4H-IN-1 (15 min) inhibits the hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) which is catalyzed by LTA4H, with an IC50 of 2 nM. |
|---|---|---|
| In Vivo | LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5460 mL | 12.7301 mL | 25.4602 mL | 50.9204 mL |
| 5mM | 0.5092 mL | 2.5460 mL | 5.0920 mL | 10.1841 mL |
| 10mM | 0.2546 mL | 1.2730 mL | 2.5460 mL | 5.0920 mL |
| 20mM | 0.1273 mL | 0.6365 mL | 1.2730 mL | 2.5460 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.