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Lyn-IN-1

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Lyn-IN-1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$900Check With Us
500mg$1500Check With Us
1g$2250Check With Us
email: [email protected]        [email protected]

Cat #: V28923 CAS #: 887650-05-7 Purity ≥ 99%

Description: Lyn-IN-1 (Bafetinib analogue), also known as INNO-406 analog and NS-187 analog, is a potent and selective dual Bcr-Abl/Lyn inhibitor, disclosed in patent WO2014169128A1.

References: From PCT Int.Appl.(2014), WO2014169128A1

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Molecular Weight (MW)576.62
Molecular FormulaC30H31F3N8O
CAS No.887650-05-7
SMILES CodeO=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CN=CN=C3)=N2)=C1)C4=CC=C(CN5C[C@@H](N(C)C)CC5)C(C(F)(F)F)=C4
SynonymsINNO406; INNO-406; INNO 406; NS187; NS-187; NS 187; Bafetinib.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7342 mL8.6712 mL17.3424 mL34.6849 mL
5mM0.3468 mL1.7342 mL3.4685 mL6.9370 mL
10mM0.1734 mL0.8671 mL1.7342 mL3.4685 mL
20mM0.0867 mL0.4336 mL0.8671 mL1.7342 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.