LY2389575

This product is for research use only, not for human use. We do not sell to patients.

LY2389575
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$140To Be Confirmed
10mg$220To Be Confirmed
50mg$750To Be Confirmed
email: [email protected]        [email protected]

Cat #: V7417 CAS #: 885104-09-6 Purity ≥ 99%

Description: LY2389575 HCl is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM) with IC50 of 190 nM. LY2389575 HCl can induce an increase in Mrc1 levels. LY2389575 HCl can also amplify the toxicity of amyloid beta (Aβ) and may be utilized in Alzheimer's disease (AD) research.

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Molecular Weight (MW)438.57
Molecular FormulaC15H16BrCl3N4
CAS No.885104-09-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsLY 2389575 LY2389575 LY-2389575
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2801 mL11.4007 mL22.8014 mL45.6028 mL
5mM0.4560 mL2.2801 mL4.5603 mL9.1206 mL
10mM0.2280 mL1.1401 mL2.2801 mL4.5603 mL
20mM0.1140 mL0.5700 mL1.1401 mL2.2801 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.