LY2119620
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1340 | Check With Us |
| 500mg | $2010 | Check With Us |
| 1g | $3015 | Check With Us |
: Cat #: V1165 CAS #: 886047-22-9 Purity ≥ 98%
Description: LY2119620 (LY 2119620; LY-2119620) is a novel, potent, specific, high-affinity and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors, the so called positive allosteric modulator (PAM).
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| Molecular Weight (MW) | 437.94 |
|---|---|
| Molecular Formula | C19H24ClN5O3S |
| CAS No. | 886047-22-9 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 87 mg/mL (198.7 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 10 mg/mL(22.8 mM) | |
| SMILES Code | O=C(C1=C(N)C2=C(C)C(Cl)=C(OCC(N3CCN(C)CC3)=O)N=C2S1)NC4CC4 |
| Synonyms | LY2119620; LY 2119620; LY-2119620 |
| Protocol | In Vitro | LY2119620 shows a modest allosteric agonism of 23.2±2.18% and 16.8±5.01% at the M2 and M4 receptors, respectively. Minimal allosteric agonism (<20%) is observed for LY2119620 at the M1, M3, and M5 receptors. The variable KB of LY2119620 for the allosteric binding site on the unoccupied receptor is found to be consistently about 1.9 to 3.4 µM. Results show a Bmax increase at the M2 receptor from 793±1.95 fmol/mg to 2850±162 fmol/mg upon addition of 10 µM LY2119620, and about a 5-fold increase in Bmax at the M4 receptor, 284±18.3 fmol/mg to 1340±42.2 fmol/mg |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2834 mL | 11.4171 mL | 22.8342 mL | 45.6684 mL |
| 5mM | 0.4567 mL | 2.2834 mL | 4.5668 mL | 9.1337 mL |
| 10mM | 0.2283 mL | 1.1417 mL | 2.2834 mL | 4.5668 mL |
| 20mM | 0.1142 mL | 0.5709 mL | 1.1417 mL | 2.2834 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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