LY2109761
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
| 5g | $6275 | Check With Us |
: Cat #: V1361 CAS #: 700874-71-1 Purity ≥ 98%
Description: LY2109761 (LY-2109761; LY 2109761) is a novel, orally bioavailable and selective dual inhibitor of transforming growth factor beta receptor I/II (TGF-β receptor type I/II: TβRI/II) with potential antitumor activity.
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 441.52 |
|---|---|
| Molecular Formula | C26H27N5O2 |
| CAS No. | 700874-71-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 2 mg/mL (4.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 0.5% CMC+0.25% Tween 80: 16 mg/mL |
| Synonyms | LY2109761; LY 2109761; LY-2109761 |
| Protocol | In Vitro | LY2109761 significantly inhibits the growth of L3.6pl/GLT soft agar colonies in a dose-dependent manner, approximately 33% at 2 μM and approximately 73% at 20 μM. Targeting TβRI/II kinase activity with LY2109761 (5 μM) almost completely inhibits basal migration of L3.6pl/GLT cells and TGF-β1-stimulated migration |
|---|---|---|
| In Vivo | LY2109761 (50 mg/kg, po) greatly reduced tumor volume and extended median survival to 45.0 days in mice. The occurrence of metastatic lesions was significantly reduced in mice treated with LY2109761, and in some of these mice, as indicated by GFP signaling, no metastatic lesions were found in the abdomen |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2649 mL | 11.3245 mL | 22.6490 mL | 45.2981 mL |
| 5mM | 0.4530 mL | 2.2649 mL | 4.5298 mL | 9.0596 mL |
| 10mM | 0.2265 mL | 1.1325 mL | 2.2649 mL | 4.5298 mL |
| 20mM | 0.1132 mL | 0.5662 mL | 1.1325 mL | 2.2649 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.