LY-2940094 tartrate

This product is for research use only, not for human use. We do not sell to patients.

LY-2940094 tartrate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$1950To Be Confirmed
100mg$3250To Be Confirmed
200mg$4875To Be Confirmed

Cat #: V24690 CAS #: 1307245-87-9 Purity ≥ 99%

Description: LY-2940094 is a nociceptin receptor antagonist potentially for the treatment of major depressive disorder and alcoholism.

References: Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.

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Molecular Weight (MW)631.05
Molecular FormulaC26H29ClF2N4O8S
CAS No.1307245-87-9
ProtocolIn VivoLY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity
Animal modelFemale Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)
Dosages3, 10, or 30 mg/kg
AdministrationP.o.; daily for 4 days
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5847 mL7.9233 mL15.8466 mL31.6932 mL
5mM0.3169 mL1.5847 mL3.1693 mL6.3386 mL
10mM0.1585 mL0.7923 mL1.5847 mL3.1693 mL
20mM0.0792 mL0.3962 mL0.7923 mL1.5847 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.