LXE408

This product is for research use only, not for human use. We do not sell to patients.

LXE408
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$340To Be Confirmed
5mg$790To Be Confirmed
email: [email protected]        [email protected]

Cat #: V40887 CAS #: 1799330-15-6 Purity ≥ 99%

Description: Description: LXE408 is a novel, potent, orally bioactive and non-competitive inhibitor of kinetoplastid-selective proteasome with an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 has the potential for treating visceral leishmaniasis.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)443.4331
Molecular FormulaC23H18FN7O2
CAS No.1799330-15-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2551 mL11.2757 mL22.5513 mL45.1026 mL
5mM0.4510 mL2.2551 mL4.5103 mL9.0205 mL
10mM0.2255 mL1.1276 mL2.2551 mL4.5103 mL
20mM0.1128 mL0.5638 mL1.1276 mL2.2551 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.