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lusutrombopag

This product is for research use only, not for human use. We do not sell to patients.

lusutrombopag
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Size Price Stock
100mg$400Check With Us
250mg$600Check With Us
500mg$900Check With Us
email: [email protected]        [email protected]

Cat #: V3880 CAS #: 1110766-97-6 Purity ≥ 98%

Description: Lusutrombopag (formerly known as S888711; S-888711; trade name: Mulpleta) is a novel orally bioavailable, small molecule agonist of thrombopoietin (TPO) receptor.

References: Kim ES, et al. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8.

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Molecular Weight (MW)591.54
Molecular FormulaC29H32Cl2N2O5S
CAS No.1110766-97-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 33 mg/mLr
Water: N/Ar
Ethanol: N/A
SMILES CodeO=C(O)/C(C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl
SynonymsS-888711; S888711; S 888711; Trade name: Mulpleta
ProtocolIn Vitrousutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.6905 mL8.4525 mL16.9050 mL33.8101 mL
5mM0.3381 mL1.6905 mL3.3810 mL6.7620 mL
10mM0.1691 mL0.8453 mL1.6905 mL3.3810 mL
20mM0.0845 mL0.4226 mL0.8453 mL1.6905 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.