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Lubiprostone (SPI-0211; RU0211)

This product is for research use only, not for human use. We do not sell to patients.

Lubiprostone (SPI-0211; RU0211)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$750Check With Us
500mg$1250Check With Us
1g$1875Check With Us
email: [email protected]        [email protected]

Cat #: V1692 CAS #: 136790-76-6 Purity ≥ 98%

Description: Lubiprostone (formerly SPI-0211; RU-0211; RU0211; Spi0211; trade name Amitiza), a bicyclic fatty acid derived from prostaglandin E1 that acts as potent activator of ClC-2 chloride channels, is an FDA-approved drug to manage idiopathic chronic constipation.

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Molecular Weight (MW)390.46
Molecular FormulaC20H32F2O5
CAS No.136790-76-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 78 mg/mL (199.8 mM)r
Water: <1 mg/mLr
Ethanol: 78 mg/mL (199.8 mM)
SynonymsRU 0211; Spi-0211; RU-0211; Spi 0211; RU 0211; RU0211; Spi0211; Lubiprostone hemiketal; Lubiprostone. trade name Amitiza.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5611 mL12.8054 mL25.6108 mL51.2216 mL
5mM0.5122 mL2.5611 mL5.1222 mL10.2443 mL
10mM0.2561 mL1.2805 mL2.5611 mL5.1222 mL
20mM0.1281 mL0.6403 mL1.2805 mL2.5611 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.