Losartan D4 Carboxylic Acid

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10mg	$1350	To Be Confirmed
25mg	$2025	To Be Confirmed
50mg	$3060	To Be Confirmed

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Cat #: V33431 CAS #: 1246820-62-1 Purity ≥ 99%

Description: Losartan D4 carboxylic acid (EXP3174 D4; EXP 3174; EXP-3174) is the tetra-deuterated form of Losartan carboxylic acid, which is a cytochrome P450-mediated carboxylic acid metabolite, and is an active metabolite of Losartan.

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Molecular Weight (MW)	440.92
Molecular Formula	C22H17D4ClN6O2
CAS No.	1246820-62-1

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2680 mL	11.3399 mL	22.6799 mL	45.3597 mL
5mM	0.4536 mL	2.2680 mL	4.5360 mL	9.0719 mL
10mM	0.2268 mL	1.1340 mL	2.2680 mL	4.5360 mL
20mM	0.1134 mL	0.5670 mL	1.1340 mL	2.2680 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.