Loratinib (PF-06463922; Lorlatinib; lorbrena)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $760 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V0613 CAS #: 1454846-35-5 Purity ≥ 98%
Description: Loratinib (formerly also known as Lorlatinib, PF-06463922; trade name: Lorbrena) is a potent, orally bioavailable, brain-penetrant, ATP-competitive, and dual ALK/ROS1 inhibitor with potential antitumor activity.
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| Molecular Weight (MW) | 406.41 |
|---|---|
| Molecular Formula | C21H19FN6O2 |
| CAS No. | 1454846-35-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 81 mg/mL (199.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 30 mg/mL warmed (73.8 mM) | |
| SMILES Code | N#CC1=C(C(CN2C)=NN1C)C3=CN=C(N)C(O[C@H](C)C4=CC(F)=CC=C4C2=O)=C3 |
| Synonyms | Lorbrena; PF06463922; PF-6463922; PF6463922; PF 6463922; PF 06463922; PF-06463922; Loratinib |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4606 mL | 12.3028 mL | 24.6057 mL | 49.2114 mL |
| 5mM | 0.4921 mL | 2.4606 mL | 4.9211 mL | 9.8423 mL |
| 10mM | 0.2461 mL | 1.2303 mL | 2.4606 mL | 4.9211 mL |
| 20mM | 0.1230 mL | 0.6151 mL | 1.2303 mL | 2.4606 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.